Modulación Terapéutica de la Homeostasis Proteica

Discovery and development of a potent LIMK2 isoform-specific degrader

Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality

Targeting the spliceosomal protein USP39 through allosteric ligands and PROTAC-induced degradation

YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition

A novel feedback loop between DYRK2 and USP28 regulates cancer homeostasis and DNA damage signaling. Cell Death & Differentiation

Long non-coding RNAs direct the SWI/SNF complex to cell-type-specific enhancers

IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy

Nucleophagy repairs toxic DNA lesions. Cell Research

The aryl hydrocarbon receptor and FOS mediate cytotoxicity induced by Acinetobacter baumannii

USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer

Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2

PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy

USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K

Inhibition of USP28 overcomes cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway

USP28: Oncogene or tumor suppressor? A unifying paradigm for squamous cell carcinoma

Minimized combinatorial CRISPR screens identify genetic interactions in autophagy

Implementation of CRISPR/Cas9 genome editing to generate murine lung cancer models that depict the mutational landscape of human disease

Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells