Cardiovascular and Respiratory Pathology/Other Systemic Diseases

Cardiovascular Pathophysiology


Cód. SSPA: IBiS-D-09

The main objective of the group is to characterize the pathophysiological mechanisms at the cellular and molecular level involved in adverse cardio-vascular remodeling and the development of heart failure. We study the molecular and cellular bases involved in the adaptive remodeling of the heart and vessels in response to the impact of cardiovascular diseases, with special emphasis on characterizing the transcriptional, post-transcriptional, and epigenetic regulation of cardiovascular diseases.

Research lines:

  • Line 1.- Adverse Remodeling and Cardiac Protection

1.1. Evaluation of the impact of inflammation in patients with acute myocardial infarction undergoing primary angioplasty. Characterization of the role of inflammatory subpopulations and microRNAs.  

1.2. Management of Ca2+ homeostasis in ischemia and reperfusion. Ca2+ channels regulated by intracellular reservoirs. Role of transcription factors and gene regulation.

1.3. Molecular mechanisms of Urocortin-2 as a cardioprotective.

  • Line 2.- Pathophysiology of the vascular wall

2.1 Molecular mechanisms of coronary angioplasty-induced restenosis. MicroRnaas as regulators of reservoir-dependent Ca2+ flow. 

2.2 Remodeling of Ca2+ homeostasis in angiogenesis. Characterization of the Notch pathway.

  • Line 3.- Structural Diseases of the Heart and 3D Bioprinting

3.1 3D bio-printing of personalized biological prostheses from CT images of patients with congenital pathologies.

3.2 Evaluation of feasibility and functionality of stem cell-repopulated prostheses.

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