Oncohematology and Genetics

Genome Dynamics and Stability

2025

Libro o artículo

SCAN1 mutant TDP1 blocks the repair of DSB induced by TOP1 activity during gene transcription and promotes genome reorganisations and cell death in quiescent cells

Diana Rubio-Contreras, Daniel Hidalgo-García, Carmen Angulo-Jiménez, Esperanza Granado-Calle, Margarita Sabio-Bonilla, Jose F. Ruiz, Fernando Gómez-Herreros

Libro o artículo

Dec. 1, 2025

Cell Death and Disease 2025 December

Libro o artículo

EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism

Joaquin Olmedo-Pelayo, Esperanza Granado-Calle, Daniel Delgado-Bellido, Laura Lobo-Selma, Carmen Jordán-Pérez, Ana T. Monteiro-Amaral, Anna C. Ehlers, Shunya Ohmura, Angel M. Carcaboso, Javier Alonso, Isidro Machado, Antonio Llombart-Bosch, Thomas G.P. Grünewald, Fernando Gómez-Herreros, Enrique de Álava

Libro o artículo

July 1, 2025

Oncogene 2025 July

2023

Libro o artículo

TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription

Diana Rubio Contreras, Fernando Gómez Herreros

Libro o artículo

Nov. 1, 2023

Nature Communications. 2023 Nov

Libro o artículo

Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

Yichao Zhao, Daniel Tabet, Diana Rubio Contreras, Arne Nedergaard Kousholt, Jochen Weile, Henrique Melo, Lisa Hoeg, Atina G. Coté, Zhen-Yuan Lin, Dheva Setiaputra, Jos Jonkers, Anne-Claude Gingras, Fernando Gómez Herreros, Frederick P. Roth, Daniel Durocher

Libro o artículo

July 1, 2023

Molecular Cell. 2023 Jul

2020

Libro o artículo

Canonical Non-Homologous End-Joining Promotes Genome Mutagenesis and Translocations Induced by Transcription-associated DNA Topoisomerase 2 Activity

Olmedo-Pelayo J, Rubio-Contreras D, Gómez-Herreros F

Libro o artículo

Sept. 1, 2020

Nucleic Acids Research. 2020 Sept

2019

Libro o artículo

DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II

Gómez-Herreros F

Libro o artículo

Dec. 1, 2019

Frontiers in Molecular Biosciences. 2019 Dec

2017

Libro o artículo

TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

Gómez-Herreros F, Zagnoli-Vieira G, Ntai I, Martínez-Macías MI, Anderson RM, Herrero-Ruíz A, Caldecott KW

Libro o artículo

Aug. 1, 2017

Nature Communications. 2017 Aug

Principal Investigator

Fernando Gómez Herreros

ORCID CV

Oncohematology and Genetics

Genome Dynamics and Stability

Libro o artículo

SCAN1 mutant TDP1 blocks the repair of DSB induced by TOP1 activity during gene transcription and promotes genome reorganisations and cell death in quiescent cells

Libro o artículo

EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism

Libro o artículo

TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription

Libro o artículo

Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

Libro o artículo

Canonical Non-Homologous End-Joining Promotes Genome Mutagenesis and Translocations Induced by Transcription-associated DNA Topoisomerase 2 Activity

Libro o artículo

DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II

Libro o artículo

TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

Infectious Diseases and the Immune System

Neurosciences

Oncohematology and Genetics

Cardiovascular and Respiratory Pathology/Other Systemic Diseases

Liver, Digestive and Inflammatory Diseases

Animal Production and Experimentation

Bioinformatics and Computational Biology

Flow cytometry service

Cell and Tissue Culture

Sterilization, Cleaning and Cryobiology

Scientific Instrumentation Service IBiS

Genomics and Sequencing

Histology

Computer Aided Design and 3D Printing

Confocal and Optical Microscopy

Proteomic

Radioactivity

Biomedical Research Support Service (SAIBIS)

iPSC and Organoids

IBiS Spaces